Ultra High-speed Ldtd Technology for Large Volume LC/MS Analyses

Thermo Fisher Scientific Inc., the world leader in serving science, announces a strategic partnership with Phytronix Technologies, a Canada-based company, for the use of Laser Diode Thermal Desorption (LDTD) technology. LDTDâ„¢ technology enhances the existing Thermo Scientific TSQ Quantumâ„¢ LC/MS product portfolio by offering ultra fast sample analysis for both quantitative and qualitative applications in high-throughput drug discovery, drug development, food safety and environmental applications.

This unique technology, consisting of a semi-conductor based laser diode, allows scientists to rapidly analyze compounds. The workflow is enhanced by simply loading the Phytronix Lazwell™ 96-well plate with the sample, and inserting the plate into the LDTD ion source operating at atmospheric pressure. The LDTD technology increases the speed of analysis of compounds by 20 to 100 times compared to established techniques based on liquid chromatography with mass spectrometry. Pharmacokinetic studies using LDTD technology can be performed in less than 10 minutes, and enzyme inhibition assays in 18 minutes – compared to 10 hours presently required with LC-MS techniques.

The LDTD™ ion source utilizes an infrared laser diode to thermally desorb the dried sample. The desorbed sample is transferred in the APCI region where it is ionized and then transferred into the MS. When configured with the TSQ Quantum, the system delivers fast and efficient quantitative and qualitative results. Applications include the analysis of sulfonamide residues in milk, analysis of explosives such as HMX, RDX, and TNT, and analysis of fatty acids in both positive and negative ion mode. One unique advantage of this technology is that it can be used in mobile units for real-time, on-location environmental testing as seen in the operation of an LDTD-based TSQ Quantum for air quality testing by the Québec Environmental Agency.

See Thermo Scientific LC/MC solutions for drug discovery and development at the American Association of Pharmaceutical Scientists (AAPS) meeting in San Diego November 12-14, 2007, Booth 709. See Phytronix Technologies for high-throughput solutions at AAPS, Booth 2045.